This is something that's really bugging me with my au_bigbang story. I'm planning on switching off between two POVs but I'm worried about how cohesive the story will be /rant

Sometimes it works, sometimes it doesn't. If the POV switch adds information to the story/plot I like it better than if it's an excuse to see what the writer's other favorite character thinks about the main pairing (usually written as "ZOMG gossip squee").

astolat's Oblivious wouldn't have worked if it didn't change POV at the mid-point.